An interactive, clinician-facing chronicle of the trials that reshaped small cell lung cancer — from the platinum–etoposide backbone and second-line topoisomerase-I inhibitors through the plateau decades, into the PD-L1 checkpoint era of the extensive-stage frontline, and the arrival of DLL3 T-cell engagers. Click any drug to trace its Phase 1→3→approval lineage; click a trial for arms, endpoints, results, and FDA/EMA milestones.
Data verified against ClinicalTrials.gov & primary literature · last reviewed Jul 2026
View
Drug class
Trial phase
Ph 1Ph 2Ph 3
Status
ApprovedInvestigationalWithdrawn / failed
Activity
Ongoing only
NCCN
In NCCN v2.2026Category 1 only
Reference
Solid outline = approvedDashed outline = investigationalDashed rose = withdrawn / failedPulsing dot = ongoing trial✓badge = FDA / EMA approvedNCCN category badge (1 / 2A / biomarker)Ambient curve = rising survival as approvals accrue
Scroll horizontally → · click a drug node to open its trial lineage
NCCN preferred regimens by stage & line of therapy
Derived from NCCN Clinical Practice Guidelines in Oncology — Small Cell Lung Cancer, Version 2.2026 (Jan 10, 2026)
Preference tiers (Preferred / Other Recommended / Useful in certain circumstances) and Categories of Evidence (1, 2A) are summarised for reference and attributed to NCCN. This is not a reproduction of the guideline; consult the authoritative, current version at nccn.org. Click a drug chip to jump to that agent’s trial lineage.